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The document discusses the role of various chromatin remodelling complexes in directing the histone variant CENP-A to centromeres. It describes how complexes like RSF, Chd1, Fft3 help load and maintain CENP-A at centromeres, while the SWI/SNF complex helps remove CENP-A from non-centromeric regions. Understanding these mechanisms is important as mis-localization of CENP-A can lead to chromosome segregation errors.

Author

10sg

Language

EN