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## Background: Maternal depression in the postpartum period confers substantial morbidity and mortality, but the definition of postpartum depression remains controversial. we investigated the heterogeneity of symptoms with the aim of identifying clinical subtypes of postpartum depression. ## Methods: Data were aggregated from the international perinatal psychiatry consortium postpartum depression: action towards causes and treatment, which represents 19 institutions in seven countries. 17,912 unique subject records with phenotypic data were submitted. we applied latent class analyses in a two-tiered approach to assess the validity of empirically defined subtypes of postpartum depression. tier one assessed heterogeneity in women with complete data on the edinburgh postnatal depression scale (epds) and tier two in those with postpartum depression case status. ## Findings: 6556 individuals were assessed in tier one and 4245 in tier two. a final model with three latent classes was optimum for both tiers. the most striking characteristics associated with postpartum depression were severity, timing of onset, comorbid anxiety, and suicidal ideation. women in class 1 had the least severe s

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Published

2015

Language

EN

Field

Psychology (Social Sciences)