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Diagnostic performance of anti-MAGEA family protein autoantibodies in esophageal squamous cell carcinoma by Guiying Sun; Huili Chen; Junfen Xia; Tiandong Li; Hua Ye; Jiaxin Li; Xiaoyue Zhang; Yifan Cheng; Keyan Wang; Jianxiang Shi; Peng Wang is a Immunology and Microbiology article available to read on EtoBox.

What is Diagnostic performance of anti-MAGEA family protein autoantibodies in esophageal squamous cell carcinoma about?

MAGEA family proteins are immunogenic and can produce corresponding autoantibodies, and we aim to evaluate the diagnostic value of anti-MAGEA family protein autoantibodies in esophageal squamous cell carcinoma (ESCC). Protein chip was used to detect the expression level of anti-MAGEA autoantibodies (IgG and IgM) in 20 mixed serum samples. Enzyme linked immunosorbent assay was adopted to determine the expression level of autoantibodies in 1019 serum samples (423 ESCC, 423 healthy control (HC), 173 benign esophageal disease (BED)), and stepwise logistic regression analysis was used for developing a diagnostic model. Eight anti-MAGEA autoantibodies were screened out based on the protein chip. The levels of 7 autoantibodies (MAGEA1-IgG, MAGEA3-IgG, MAGEA3-IgM, MAGEA4-IgG, MAGEA6-IgG, MAGEA10-IgG, MAGEA12-IgG) in ESCC were significantly higher than that in HC, and the levels of anti-MAGEA1 IgG, anti-MAGEA3-IgG, anti-MAGEA4-IgG, anti-MAGEA10-IgG and anti-MAGEA12-IgG autoantibodies in ESCC group were significantly higher than those in BED group. The area under curve (AUC), sensitivity and specificity of the logistic regression model (MAGEA1-IgG, MAGEA4-IgG, MAGEA6-IgG, MAGEA12-IgG) in the

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Author

Guiying Sun; Huili Chen; Junfen Xia; Tiandong Li; Hua Ye; Jiaxin Li; Xiaoyue Zhang; Yifan Cheng; Keyan Wang; Jianxiang Shi; Peng Wang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Immunology and Microbiology (Life Sciences)