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Long-Term Outcomes of Testosterone Treatment in Men: A T4DM Post-Randomisation Observational Follow-Up Study by David J Handelsman; Mathis Grossmann; Bu B Yeap; Bronwyn GA Stuckey; Nandini Shankara-Narayana; Ann J Conway; Warrick J Inder; Robert I McLachlan; Carolyn Allan; Alicia J Jenkins; David Jesudason; Karen Bracken; Gary A Wittert is a Medicine article available to read on EtoBox.

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## Abstract ## Context The T4DM study randomized 1007 men with impaired glucose tolerance or newly diagnosed diabetes to testosterone undecanoate (TU, 1000 mg) or matching placebo (P) injections every 12 weeks for 24 months with a lifestyle program with T treatment reducing diabetes diagnosis by 40%. ## Design A follow-up email survey after a median of 5.1 years since last injection obtained 599 (59%) completed surveys (316 T, 283 P) with participants in follow-up survey like non-participants in 23 anthropometric and demographic variables. ## Results Randomization to TU associated with stronger belief in study benefits during (64% vs 49%, p < 0.001) but no longer after the study (44% vs 40%, p = 0.07) and high interest in future studies. At T4DM entry, 25% had sleep apnea with new diagnosis more frequent on TU (3.0% vs 0.4%, p = 0.03) during, but not after, the study. Post-study resuming prescribed testosterone treatment was more frequent among TU treated men (6% vs 2.8%, p = 0.03). Five years after cessation of TU treatment there was no difference in self-reported rates of new diagnosis of diabetes, prostate or cardiovascular disease nor change in weight maintenance or weight loss

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Author

David J Handelsman; Mathis Grossmann; Bu B Yeap; Bronwyn GA Stuckey; Nandini Shankara-Narayana; Ann J Conway; Warrick J Inder; Robert I McLachlan; Carolyn Allan; Alicia J Jenkins; David Jesudason; Karen Bracken; Gary A Wittert

Publisher

The Endocrine Society

Published

2023

Field

Medicine (Health Sciences)