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Activation of Smooth Muscle and Myenteric Plexus Cells of Jejunum via Toll-like Receptor 4 by Cristiano Rumio; Dario Besusso; Francesca Arnaboldi; Marco Palazzo; Silvia Selleri; Silvia Gariboldi; Shizuo Akira; Satoshi Uematsu; Paola Bignami; Valerio Ceriani; Sylvie Ménard; Andrea Balsari is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Activation of Smooth Muscle and Myenteric Plexus Cells of Jejunum via Toll-like Receptor 4 about?

## Abstract The cell types of the gut expressing Toll‐like receptor 4, which recognizes specifically bacterial lipopolysaccharides, as well as the functionality of this receptor, have remained controversial. We aimed to clarify these issues. Mouse and human intestinal specimens were stained immunohistochemically to detect Toll‐like receptor 4 expression. Smooth muscle and myenteric plexus cells but not enterocytes revealed receptor expression. Murine intestinal smooth muscle and myenteric plexus cells but not enterocytes showed nuclear translocation of nuclear factor‐kappaB after in vivo stimulation with lipopolysaccharide. Moreover, lipopolysaccharide added to human jejunum biopsies free of epithelial cells induced release of interleukin‐8 (IL‐8). We can conclude that Toll‐like receptor 4 is not expressed in epithelial layer, but rather on smooth muscle and myenteric plexus cells and that expression is functional. The expression of Toll‐like receptor 4 on smooth muscle and myenteric plexus cells is consistent with the possibility that these cells are involved in intestinal immune defense; the low or absent expression of Toll‐like receptor 4 on enterocytes might explain the intesti

Who reads Activation of Smooth Muscle and Myenteric Plexus Cells of Jejunum via Toll-like Receptor 4?

Author

Cristiano Rumio; Dario Besusso; Francesca Arnaboldi; Marco Palazzo; Silvia Selleri; Silvia Gariboldi; Shizuo Akira; Satoshi Uematsu; Paola Bignami; Valerio Ceriani; Sylvie Ménard; Andrea Balsari

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)