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Anti‐neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression‐like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF‐κB pathway in rats exposed to chronic unpredictable mild stress by Yu Chen; Yue Zhang; Junying Wang; Shaoyuan Li; Yifei Wang; Zixuan Zhang; Jinling Zhang; Chen Xin; Yu Wang; Peijing Rong is a Neuroscience article available to read on EtoBox.
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## Abstract ## Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a vital neuromodulation for the treatment of depression, but its antidepressant molecular mechanism is unclear. The α7 nicotinic acetylcholine receptor (α7nAchR) is a key mediator of the vagus nerve that mediates its anti‐inflammatory efficacy. Here, we investigated whether the antidepressant effect of taVNS in chronic unpredicted mild stress (CUMS)‐exposed rats works through the α7nAchR/JAK2/STAT3/NF‐κB pathway. ## Methods The depression model was established by CUMS for continuous 6 weeks in rats. From the 4th week of the experiment, CUMS‐exposed rats were subjected to taVNS for 3 weeks. To clarify the role of α7nAchR in the antidepressant effect of taVNS, we used α7nAchR^−/−^ gene knockout rats. The sucrose preference test (SPT), open field test (OFT), and forced swimming test (FST) were used to evaluate depression‐like behaviors of rats. Immunofluorescent staining was used to observe the morphology of microglia in the hypothalamus. Western blot was used to examine the protein expression of α7nAchR, p‐JAK2, p‐STAT3, IL‐1β, NF‐κB p65, and p‐NF‐κB p65 in the hypothalamus. ## Results Depression‐li
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- Author
- Yu Chen; Yue Zhang; Junying Wang; Shaoyuan Li; Yifei Wang; Zixuan Zhang; Jinling Zhang; Chen Xin; Yu Wang; Peijing Rong
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)