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Parsing Variability in Borderline Personality Disorder: a Meta-analysis of Neuroimaging Studies by Degasperi, Giorgia (author);Cristea, Ioana Alina (author);Di Rosa, Elisa (author);Costa, Cristiano (author);Gentili, Claudio (author) is a scholarly article available to read on EtoBox.

What is Parsing Variability in Borderline Personality Disorder: a Meta-analysis of Neuroimaging Studies about?

Though a plethora of functional magnetic resonance imaging (fMRI) studies explored the neurobiological underpinnings of borderline personality disorder (BPD), findings across different tasks were divergent. We conducted a systematic review and activation likelihood estimation (ALE) meta-analysis on the fMRI studies conducted in BPD patients compared to healthy controls (HC). We systematically searched PubMed and PsychINFO from inception until July 9th 2020 using combinations of database-specific terms like ‘fMRI’, ‘Neuroimaging’, ‘borderline’. Eligible studies employed task-based fMRI of the brain in participants of any age diagnosed with BPD compared to HC, during any behavioral task and providing a direct contrast between the groups. From 762 entries, we inspected 92 reports full-texts and included 52 studies (describing 54 experiments). Across all experiments, the HC > BPD and BPD > HC meta-analyses did not yield any cluster of significant convergence of differences. Analyses restricted to studies of emotion processing revealed two significant clusters of activation in the bilateral hippocampal/amygdala complex and anterior cingulate for the BPD > HC meta-analysis. Fail-safe N a

Author

Degasperi, Giorgia (author);Cristea, Ioana Alina (author);Di Rosa, Elisa (author);Costa, Cristiano (author);Gentili, Claudio (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN