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BAI1 by Peter Tu is a document available to read on EtoBox.
1) Mice lacking the brain-specific angiogenesis inhibitor 1 (BAI1) exhibit severe deficits in hippocampus-dependent spatial learning and memory, accompanied by enhanced long-term potentiation (LTP), impaired long-term depression (LTD), and thinning of the postsynaptic density (PSD) at hippocampal synapses. 2) BAI1 prevents degradation of the canonical PSD component PSD-95 through interaction with the E3 ubiquitin ligase MDM2, which regulates PSD-95 stability. 3) Restoring PSD-95 expression in the hippoca
- Author
- Peter Tu
- Language
- EN