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Characteristics of Membrane and Cytosol Forms of the Mammary Tumor Glycoprotein Molecule Mtgp in Human Breast Carcinoma Cell Cultures and Tumors by Julia P. Leung; Walter A. Nelson‐Rees; George E. Moore; Relda Cailleau; Thomas S. Edgington is a Medicine article available to read on EtoBox.
What is Characteristics of Membrane and Cytosol Forms of the Mammary Tumor Glycoprotein Molecule Mtgp in Human Breast Carcinoma Cell Cultures and Tumors about?
## Abstract The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set **MTGP**, a trace and apparently tumor‐specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both cytosol and membrane‐associated forms of **MTGP** were analyzed, and each was phenotyped by reference to isoelectric point and buoyant density. All cells or tissues of mammary carcinoma origin contained membrane **MTGP**, whereas cytosol **MTGP** was undetectable in cell cultures from half of the mammary carcinomas. Neither membrane nor cytosol **MTGP** were detectable in cells other than mammary carcinomas. Cytosol **MTGP** could be assigned to three groups by reference to presence, isoelectric point and buoyant density. Membrane **MTGP** also exhibited heterogeneity between different tumors and could be assigned to three groups by isoelectric point and buoyant density. Each form of **MTGP** was homogeneous for a given single tumor or cell culture and retained its phenotypic features with passage and cloning. Four general types of **MTGP** are proposed,
Who reads Characteristics of Membrane and Cytosol Forms of the Mammary Tumor Glycoprotein Molecule Mtgp in Human Breast Carcinoma Cell Cultures and Tumors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Julia P. Leung; Walter A. Nelson‐Rees; George E. Moore; Relda Cailleau; Thomas S. Edgington
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1981
- Language
- EN
- Field
- Medicine (Health Sciences)