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Microbial transformation of bile acids. A unified scheme for bile acid degradation, and hydroxylation of bile acids by Prof. Dr. S. Hayakawa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Through the isolation and identification of a wide variety of degradation products formed from bile acids by microorganisms, a unified scheme for the complete degradation of bile acids to carbon dioxide and water has been proposed and discussed. The proposed degradative pathways mainly consist of the following steps: natural C~24~ 3‐hydroxy bile acids → 3‐oxo bile acids → Δ^4^‐3‐oxo bile acids → → C~16~ or C~18~ perhydroindane derivative (at least in two ways) → → (4→)‐4‐methyl‐5‐oxo‐octanedioic acid (at least in three ways) → → CO~2~ and H~2~O. A microbial hydroxylation method for the preparation of bile acid samples was investigated which could be used as reference standards in the analysis of bile acids in biological materials and also as materials for studying the function of bile acids. The particular fungi, __Curcularia lunata__ NRRL‐2380, __Helicostylum piriforme__ ATTC‐8992 and __Pestalotia foedans__ ATCC‐11817 effected the 1β‐, 11β‐, 12β‐, 15α‐ or 15β‐hydroxylation of certain bile acids and gave the following products: 1β,3α‐, 3α,12β‐ and 3α,15β‐dihydroxy‐5β‐cholan −24‐oic acids, 3α,12β,15α‐ and 3α,12β, 15β‐trihydroxy‐5β‐cholan‐24‐oic acids and 12β,15β‐dihydrox

Who reads Microbial transformation of bile acids. A unified scheme for bile acid degradation, and hydroxylation of bile acids?

Author

Prof. Dr. S. Hayakawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Akademie Verlag; Wiley (ISSN 0233-111X)

Published

1982

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)