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What is Enhanced PPA*HCl Yield via Akabori Method about?
The document describes an improved method for synthesizing racemic PPA*HCl via the Akabori reaction. Key steps include: (1) Reacting benzaldehyde and DL-alanine at 140 Celsius for 3 hours, then cooling and adding AcOH in toluene and stirring for 20 minutes, (2) Adding HCl and refluxing for 3 hours to make the mixture strongly acidic, (3) Separating the organic and aqueous layers and extracting the aqueous layer with DCM, (4) Treating the aqueous layer with NaHCO3 and NaOH to separate an oily layer containin
- Author
- Robert Bonka
- Language
- EN