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The structural basis of Bcl-2 mediated cell death regulation in hydra by Suresh Banjara; Jaison D Sa; Mark G. Hinds; Marc Kvansakul is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Apoptosis is regulated by evolutionarily conserved signaling pathways to remove damaged, diseased or unwanted cells. Proteins homologous to the B-cell lymphoma 2 (Bcl-2) family of proteins, the primary arbiters of mitochondrially mediated apoptosis, are encoded by the cnidarian __Hydra vulgaris__. We mapped interactions between pro-survival and pro-apoptotic Bcl-2 proteins of __H. vulgaris__ by affinity measurements between Hy-Bcl-2-4, the sole confirmed pro-survival Bcl-2 protein, with BH3 motif peptides of two Bcl-2 proteins from hydra that displayed pro-apoptotic activity, Hy-Bak1 and Hy-BH3-only-2, and the BH3 motif peptide of the predicted pro-apoptotic protein Hy-Bax. In addition to peptides from hydra encoded pro-apoptotic proteins, Hy-Bcl-2-4 also engaged BH3 motif peptides from multiple human pro-apoptotic Bcl-2 proteins. Reciprocally, human pro-survival Bcl-2 proteins Bcl-2, Bcl-x~L~, Bcl-w, Mcl-1 and A1/Bfl-1 bound to BH3 spanning peptides from hydra encoded pro-apoptotic Hy-Bak1, Hy-BH3-only and Hy-Bax. The molecular details of the interactions were determined from crystal structures of Hy-Bcl-2-4 complexes with BH3 motif peptides of Hy-Bak1 and Hy-Bax. Our findings sug

Who reads The structural basis of Bcl-2 mediated cell death regulation in hydra?

Author

Suresh Banjara; Jaison D Sa; Mark G. Hinds; Marc Kvansakul

Publisher

Portland Press Ltd.

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)