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Can I read Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells on EtoBox?
Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells by Valérie Perron; Daniel Rabouin; Éric Asselin; Sophie Parent; René C.-Gaudreault; Gervais Bérubé is a Chemistry article available to read on EtoBox.
What is Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells about?
The synthesis of two new highly potent 17β-estradiol-linked platinum(II) complexes is described. The new molecules are linked at position 16 of the steroid nucleus with an alkyl chain. They are made from estrone in nine chemical steps with an overall yield exceeding 10%. The biological activity of these compounds was evaluated in vitro on estrogen dependent and independent (ER+ and ER−) human breast tumor cell lines: MCF-7 and MDA-MB-231. The novel compounds prove to be highly cytotoxic against breast cancer cell lines. The most cytotoxic derivative shows high affinity for the estrogen receptor alpha.
Who reads Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Valérie Perron; Daniel Rabouin; Éric Asselin; Sophie Parent; René C.-Gaudreault; Gervais Bérubé
- Publisher
- Elsevier BV
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)