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The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey by Luis Corral-Gudino; Elvira González-Vázquez; Ismael Calero-Paniagua; Laura Pérez-Garrido; Ivan Cusacovich; Alicia Rivas-Lamazares; Alba Quesada-Moreno; Ana González-Fernández; Damian Mora-Peña; Jose Luis Lerma-Márquez; Javier del-Pino-Montes is a Medicine article available to read on EtoBox.

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The different sets of criteria for diagnosis or classification of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) lead to numerous overlapping and reclassified diagnoses in clinical practice. We designed this study to assess the difficulties in classifying patients with AAV. As a secondary objective, different variables were tested to predict prognosis. We conducted a retrospective chart review in a Western Spain multicentre survey. A total of 115 adult patients diagnosed with AAV from 2002 to 2013 and followed for at least 3 years were included. They were classified according to (1) Chapel Hill Consensus Conference (CHCC), (2) European Medicines Agency algorithm and (3) French Vasculitis Study Group/European Vasculitis Society phenotypes. Fifty-three patients (46%) had neither distinctive histopathological data of a single AAV definition nor any surrogate markers for granulomatous inflammation and thus did not fulfill any diagnostic criteria. Ocular, ear, nose, throat, skin, and lung involvement were more frequent with proteinase 3 (PR3) antibodies, whereas peripheral neuropathy was more frequent with myeloperoxidase (MPO) antibodies. When the disease was severe a

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Author

Luis Corral-Gudino; Elvira González-Vázquez; Ismael Calero-Paniagua; Laura Pérez-Garrido; Ivan Cusacovich; Alicia Rivas-Lamazares; Alba Quesada-Moreno; Ana González-Fernández; Damian Mora-Peña; Jose Luis Lerma-Márquez; Javier del-Pino-Montes

Publisher

Springer Science and Business Media LLC

Published

2019

Language

EN

Field

Medicine (Health Sciences)