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Association of macromolecular prodrugs consisting of adriamycin bound to poly(L-glutamic acid) by Nukui, Masahiro ;Hoes, Kees ;van den Berg, Hans ;Feijen, Jan is a Chemistry article available to read on EtoBox.

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## Abstract Soluble macromolecular conjugates for the controlled delivery of the strongly hydrophobic antitumor drug adriamycin (ADR) were prepared. The association behaviour of two types of these amphiphilic conjugates consisting of ADR bound to poly(L‐glutamic acid) (PGA) in aqueous solution was investigated using absorbance and fluorescence spectroscopy as well as GPC and lowangle laser light scattering (LALLS) measurements. ADR was bound via the aminoribosyl moiety either directly with PGA side‐chain groups or via oligopeptide spacer groups. UV/VIS, GPC and LALLS data showed that in buffer solution both ADR conjugates associate intermolecularly. The data of the directly bound ADR conjugates are consistent with the presence of multimers of different degrees of association in equilibrium with single polymer chains. In contrast, spacer‐containing ADR conjugates associate to give stable uniform multimers. UV/VIS and fluorescence spectroscopy performed at very low conjugate concentration show that polymer‐bound ADR residues associate intramolecularly as well. The degree of intra‐ and intermolecular association of the conjugate‐bound ADR molecules depends on the type of conjugate, AD

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Author

Nukui, Masahiro ;Hoes, Kees ;van den Berg, Hans ;Feijen, Jan

Publisher

Wiley (John Wiley & Sons); Wiley (ISSN 0025-116X)

Published

1991

Language

EN

Field

Chemistry (Physical Sciences)