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Pituitary Stalk Interruption Syndrome: Phenotype, Predictors, and Pathophysiology of Perinatal Events by Chakra Diwaker; Puja Thadani; Saba Samad Memon; Vijaya Sarathi; Anurag Ranjan Lila; Sneha Arya; Brijesh Krishnappa; Manjiri Karlekar; Virendra A. Patil; Nalini Shah; Tushar Bandgar is a Medicine article available to read on EtoBox.
What is Pituitary Stalk Interruption Syndrome: Phenotype, Predictors, and Pathophysiology of Perinatal Events about?
## Purpose: There is limited data regarding pituitary stalk interruption syndrome (psis) from india. moreover, the pathophysiological link between perinatal events and psis is unclear. we aim to elucidate the predictors of psis among patients with growth hormone deficiency (ghd) and perinatal events in psis by comparing cohorts of psis and genetically proven ghd without psis. ## Methods: Among 179 ghd patients, 56 psis and 70 genetically positive ghd (52-ghrhr, 15-pou1f1, and 3-prop1) patients were included. perinatal events, clinical anomalies, pituitary hormone deficiency, and imaging findings were recorded. we compared psis-isolated ghd (psis-ighd) subgroup with ghrhr-ighd and psis-combined pituitary hormone deficiency (psis-cphd) subgroup with pou1f1/prop1-cphd. ## Results: Psis patients (45 males, median age: 12.5 years) most commonly presented with short stature. at last follow-up (median age: 17.35 years), gonadal (during pubertal-age), thyroid and cortisol axes were affected in 81.6%, 62.5%, and 62.5%. 10/13 (77%) of psis children with initial ighd diagnosis manifested hypogonadism during pubertal age. male predominance, sporadic presentation, and clinical anomalies were si
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- Author
- Chakra Diwaker; Puja Thadani; Saba Samad Memon; Vijaya Sarathi; Anurag Ranjan Lila; Sneha Arya; Brijesh Krishnappa; Manjiri Karlekar; Virendra A. Patil; Nalini Shah; Tushar Bandgar
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)