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Inhibition of Proliferation of a Colon Cancer Cell Line by Indole-3-carbinol by H. R. Frydoonfar; D. R. McGrath; A. D. Spigelman is a Medicine article available to read on EtoBox.

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## Objective To observe the effect of Indole‐3‐carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line. ## Methods Cell proliferation was measured using three different methods; ^3^H‐thymidine incorporation, cell count and colourimetric assay. ## Results Each method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 mM. ## Conclusion The present study demonstrates for the first time the capacity of indole‐3‐carbinol to inhibit cell proliferation of a colon cancer cell line.

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Author

H. R. Frydoonfar; D. R. McGrath; A. D. Spigelman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1462-8910)

Published

2002

Language

EN

Field

Medicine (Health Sciences)