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Can I read Neuroimaging evidence of white matter inflammation in newly diagnosed systemic lupus erythematosus: White Matter Inflammation in SLE on EtoBox?
Neuroimaging evidence of white matter inflammation in newly diagnosed systemic lupus erythematosus: White Matter Inflammation in SLE by Amy E. Ramage; Peter T. Fox; Robin L. Brey; Shalini Narayana; Matthew D. Cykowski; Mohammad Naqibuddin; Margaret Sampedro; Stephen L. Holliday; Crystal Franklin; Daniel J. Wallace; Michael H. Weisman; Michelle Petri is a Medicine article available to read on EtoBox.
What is Neuroimaging evidence of white matter inflammation in newly diagnosed systemic lupus erythematosus: White Matter Inflammation in SLE about?
Objective. Central nervous system (CNS) involvement occurs frequently in systemic lupus erythematosus (SLE) and frequently results in morbidity. The primary pathophysiology of CNS involvement in SLE is thought to be inflammation secondary to autoantibody-mediated vasculitis. Neuroimaging studies have shown hypometabolism (representing impending cell failure) and atrophy (representing late-stage pathology), but not inflammation. The purpose of this study was to detect the presence and regional distribution of inflammation (hypermetabolism) and tissue failure, apoptosis, or atrophy (hypometabolism). Methods. Eighty-five patients with newly diagnosed SLE, who had no focal neurologic symptoms, were studied. Disease activity was quantified using the Safety of Estrogens in Lupus Erythematosus: National Assessment version of the SLE Disease Activity Index (SELENA-SLEDAI), a validated index of SLE-related disease activity. 18 Fluorodeoxyglucose (FDG) positron emission tomography (PET) images of glucose uptake were analyzed by visual inspection and as group statistical parametric images, using the SELENA-SLEDAI score as the analysis regressor. Results. SELENA-SLEDAI-correlated increases in
Who reads Neuroimaging evidence of white matter inflammation in newly diagnosed systemic lupus erythematosus: White Matter Inflammation in SLE?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Amy E. Ramage; Peter T. Fox; Robin L. Brey; Shalini Narayana; Matthew D. Cykowski; Mohammad Naqibuddin; Margaret Sampedro; Stephen L. Holliday; Crystal Franklin; Daniel J. Wallace; Michael H. Weisman; Michelle Petri
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)