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Dissemination of Neisseria gonorrhoeae with decreased susceptibility to extended-spectrum cephalosporins in Southern China, 2021: a genome-wide surveillance from 20 cities by Liao, Yiwen (author);Xie, Qinghui (author);Li, Xiaoxiao (author);Yin, Xiaona (author);Wu, Xingzhong (author);Liu, Mingjing (author);Pan, Yuying (author);Zeng, Lihong (author);Yang, Jianjiang (author);Feng, Zhanqin (author);Qin, Xiaolin (author);Zheng, Heping (author) is a Medicine article available to read on EtoBox.

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## Background Antimicrobial resistance (AMR) of untreatable gonococcal infection is an emerging threat, especially in Guangdong, a prosperous province in Southern China. ## Methods __N.gonorrhoeae__ was isolated from 20 cities in Guangdong and determined antimicrobial susceptibility. Through whole-genome sequencing (WGS), multilocus sequence typing (MLST), __N.gonorrhoeae__ multiantigen sequence typing (NG-MAST), and __N.gonorrhoeae__ sequence typing for antimicrobial resistance (NG-STAR) were obtained based on the PubMLST database (https://pubmlst.org/). Phylogenetic analysis was used for dissemination and tracking analysis. ## Results Antimicrobial susceptibility was performed on 347 isolates, and 50 isolates were identified as decreased susceptibility (DS) to cephalosporins. Of which 16.0% (8/50) were ceftriaxone DS, 38.0% (19/50) were cefixime DS, and 46.0% (23/50) were both ceftriaxone and cefixime DS. In all, the dual-resistant rate of the cephalosporin-DS isolates was 96.0% for penicillin and 98.0% for tetracycline-resistant, and 10.0% (5/50) were resistant to azithromycin. All cephalosporin-DS isolates were resistant to ciprofloxacin but sensitive to spectinomycin. The pred

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Author

Liao, Yiwen (author);Xie, Qinghui (author);Li, Xiaoxiao (author);Yin, Xiaona (author);Wu, Xingzhong (author);Liu, Mingjing (author);Pan, Yuying (author);Zeng, Lihong (author);Yang, Jianjiang (author);Feng, Zhanqin (author);Qin, Xiaolin (author);Zheng, Heping (author)

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)