Can I read Prognostic Significance of Parapharyngeal Extension in Nasopharyngeal Carcinoma Treated with Intensity Modulated Radiotherapy on EtoBox?

Prognostic Significance of Parapharyngeal Extension in Nasopharyngeal Carcinoma Treated with Intensity Modulated Radiotherapy by D. Kwong; J. Sham; G. Au is a Medicine article available to read on EtoBox.

What is Prognostic Significance of Parapharyngeal Extension in Nasopharyngeal Carcinoma Treated with Intensity Modulated Radiotherapy about?

overall outcome, we have performed preoperative concurrent chemoradiation therapy (CCRT) with TS-1, an oral fluoropyrimidine derivative, in patients with advanced oral SCC. The purpose of our study was to determine the feasibility and efficacy of preoperative CCRT with S-1 in patients with T4 oral SCC. Materials/Methods: Only patients with histologically-proven T4 oral SCC were included. Radiotherapy (total dose 30 Gy) was delivered in 2-Gy daily fractions over a period of 3 weeks. Concurrently, S-1 (80 mg/m 2 /day) was administered orally twice-a-day for 14 consecutive days. Surgical resection with reconstruction was performed 3 -4 weeks after the completion of CCRT. Radical en bloc resection was based on the degree of tumor extension determined before CCRT. Patients who were not surgically treated due to technically and/or medically unresectable disease or their refusal to undergo surgery received one additional cycle of the similar CCRT with a total dose of 30 Gy and oral S-1. Results: Between January 2004 and December 2007, we enrolled 46 patients. All underwent radiotherapy as planned; however, oral S-1 was discontinued in 3 patients who manifested acute toxicity. The toxiciti

Who reads Prognostic Significance of Parapharyngeal Extension in Nasopharyngeal Carcinoma Treated with Intensity Modulated Radiotherapy?

Author

D. Kwong; J. Sham; G. Au

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2009

Language

EN

Field

Medicine (Health Sciences)