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Can I read Sporozoite Immunization: Innovative Translational Science to Support the Fight Against Malaria on EtoBox?
Sporozoite Immunization: Innovative Translational Science to Support the Fight Against Malaria by Thomas L. Richie; L.W. Preston Church; Tooba Murshedkar; Peter F. Billingsley; Eric R. James; Mei-Chun Chen; Yonas Abebe; Natasha KC; Sumana Chakravarty; David Dolberg; Sara A. Healy; Halimatou Diawara; Mahamadou S. Sissoko; Issaka Sagara; David M. Cook; Judith E. Epstein; Benjamin Mordmüller; Melissa Kapulu; Andrea Kreidenweiss; Blandine Franke-Fayard; Selidji T. Agnandji; María-Silvia A. López Mikue; Matthew B.B. McCall; Laura Steinhardt; Martina Oneko; Ally Olotu; Ashley M. Vaughan; James G. Kublin; Sean C. Murphy; Said Jongo; Marcel Tanner; Sodiomon B. Sirima; Matthew B. Laurens; Claudia Daubenberger; Joana C. Silva; Kirsten E. Lyke; Chris J. Janse; Meta Roestenberg; Robert W. Sauerwein; Salim Abdulla; Alassane Dicko; Stefan H. I. Kappe; B. Kim Lee Sim; Patrick E. Duffy; Peter G. Kremsner; Stephen L. Hoffman is a Medicine article available to read on EtoBox.
What is Sporozoite Immunization: Innovative Translational Science to Support the Fight Against Malaria about?
## Introduction: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for __Plasmodium falciparum__ (Pf), the deadliest human malaria parasite. ## Areas covered: Sporozoites (SPZ), the parasite stage transmitted by __Anopheles__ mosquitoes to humans, are the only vaccine immunogen achieving >90% efficacy against Pf infection. This review describes >30 clinical trials of PfSPZ vaccines in the U.S.A., Europe, Africa, and Asia, based on first-hand knowledge of the trials and PubMed searches of ‘sporozoites,’ ‘malaria,’ and ‘vaccines.’ ## Expert opinion: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80–100% efficacious against homologous controlled human malaria infection (CHMI) and provide 18–19 months protection without boosting in Africa. Second generation chemo-attenuated PfSPZ are more potent, 100% efficacious against stringent heterologous (variant strain) CHMI, but require a co-administered drug, raising safety concerns. Third generation, late liver stage-arr
Who reads Sporozoite Immunization: Innovative Translational Science to Support the Fight Against Malaria?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Thomas L. Richie; L.W. Preston Church; Tooba Murshedkar; Peter F. Billingsley; Eric R. James; Mei-Chun Chen; Yonas Abebe; Natasha KC; Sumana Chakravarty; David Dolberg; Sara A. Healy; Halimatou Diawara; Mahamadou S. Sissoko; Issaka Sagara; David M. Cook; Judith E. Epstein; Benjamin Mordmüller; Melissa Kapulu; Andrea Kreidenweiss; Blandine Franke-Fayard; Selidji T. Agnandji; María-Silvia A. López Mikue; Matthew B.B. McCall; Laura Steinhardt; Martina Oneko; Ally Olotu; Ashley M. Vaughan; James G. Kublin; Sean C. Murphy; Said Jongo; Marcel Tanner; Sodiomon B. Sirima; Matthew B. Laurens; Claudia Daubenberger; Joana C. Silva; Kirsten E. Lyke; Chris J. Janse; Meta Roestenberg; Robert W. Sauerwein; Salim Abdulla; Alassane Dicko; Stefan H. I. Kappe; B. Kim Lee Sim; Patrick E. Duffy; Peter G. Kremsner; Stephen L. Hoffman
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)