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Can I read Surgical Treatment and Prognosis of Gastrinoma on EtoBox?
Surgical Treatment and Prognosis of Gastrinoma by Jeffrey A. Norton is a Medicine article available to read on EtoBox.
What is Surgical Treatment and Prognosis of Gastrinoma about?
Zollinger-Ellison syndrome (ZES) is a clinical syndrome with severe peptic ulcer disease and diarrhea caused by gastric acid hypersecretion secondary to a neuroendocrine tumour that secretes excessive amounts of the hormone gastrin (gastrinoma). Gastrinomas occur in a familial and a sporadic form. Patients with gastrinoma in the familial setting of Multiple Endocrine Neoplasia type 1 (MEN-1) are seldom, if ever, cured of Zollinger-Ellison syndrome by the current non-Whipple operations to remove duodenal and pancreatic gastrinoma. Surgery is currently used in these patients to deal with the malignant nature of pancreatic or duodenal neuroendocrine tumours. Malignant potential is best determined by tumour size. Tumours that are greater than 2 cm in size should be excised. In the sporadic setting, cure occurs in a significant proportion of patients (50%) by surgical resection of gastrinoma. Duodenotomy has improved both the tumour detection rate and the cure rate and should be routinely done. Whipple pancreaticoduodenectomy results in the highest probability of cure in both sporadic and MEN-1 gastrinoma patients as it removes the entire gastrinoma triangle. However, the excellent long
Who reads Surgical Treatment and Prognosis of Gastrinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jeffrey A. Norton
- Publisher
- Elsevier Science; Elsevier ; Bailliere Tindall Ltd; Elsevier BV (ISSN 1521-6918)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)