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Can I read Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial on EtoBox?
Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial by Byeong-Keuk Kim; Sung-Jin Hong; Yun-Hyeong Cho; Kyeong Ho Yun; Yong Hoon Kim; Yongsung Suh; Jae Young Cho; Ae-Young Her; Sungsoo Cho; Dong Woon Jeon; Sang-Yong Yoo; Deok-Kyu Cho; Bum-Kee Hong; Hyuckmoon Kwon; Chul-Min Ahn; Dong-Ho Shin; Chung-Mo Nam; Jung-Sun Kim; Young-Guk Ko; Donghoon Choi; Myeong-Ki Hong; Yangsoo Jang; for the TICO Investigators is a Medicine article available to read on EtoBox.
What is Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial about?
## Importance: Discontinuing aspirin after short-term dual antiplatelet therapy (dapt) was evaluated as a bleeding reduction strategy. however, the strategy of ticagrelor monotherapy has not been exclusively evaluated in patients with acute coronary syndromes (acs). ## Objective: To determine whether switching to ticagrelor monotherapy after 3 months of dapt reduces net adverse clinical events compared with ticagrelor-based 12-month dapt in patients with acs treated with drug-eluting stents. ## Design, setting, and participants: A randomized multicenter trial was conducted in 3056 patients with acs treated with drug-eluting stents between august 2015 and october 2018 at 38 centers in south korea. follow-up was completed in october 2019. ## Interventions: Patients were randomized to receive ticagrelor monotherapy (90 mg twice daily) after 3-month dapt (n = 1527) or ticagrelor-based 12-month dapt (n = 1529). ## Main outcomes and measures: The primary outcome was a 1-year net adverse clinical event, defined as a composite of major bleeding and adverse cardiac and cerebrovascular events (death, myocardial infarction, stent thrombosis, stroke, or target-vessel revascularization). prespe
Who reads Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial?
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- Author
- Byeong-Keuk Kim; Sung-Jin Hong; Yun-Hyeong Cho; Kyeong Ho Yun; Yong Hoon Kim; Yongsung Suh; Jae Young Cho; Ae-Young Her; Sungsoo Cho; Dong Woon Jeon; Sang-Yong Yoo; Deok-Kyu Cho; Bum-Kee Hong; Hyuckmoon Kwon; Chul-Min Ahn; Dong-Ho Shin; Chung-Mo Nam; Jung-Sun Kim; Young-Guk Ko; Donghoon Choi; Myeong-Ki Hong; Yangsoo Jang; for the TICO Investigators
- Publisher
- American Medical Association (AMA)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)