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What is Enhancing Therapeutic Protein Half-Life about?

This review discusses the manipulation of sialic acid content in recombinant therapeutic proteins to enhance their pharmacokinetic and pharmacodynamic properties, particularly focusing on their circulatory half-life. Sialic acid plays a crucial role in preventing the recognition and clearance of these proteins by the hepatic asialoglycoprotein receptor, thereby improving their therapeutic efficacy. Various strategies, including glycoengineering and polysialylation, are explored to optimize the sialylation o

Author

729648zx

Language

EN