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Exosomes from human urine‐derived stem cells enhanced neurogenesis via miR‐26a/HDAC6 axis after ischaemic stroke by Xiaozheng Ling; Guowei Zhang; Yuguo Xia; Qingwei Zhu; Juntao Zhang; Qing Li; Xin Niu; Guowen Hu; Yunlong Yang; Yang Wang; Zhifeng Deng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Exosomes from human urine‐derived stem cells enhanced neurogenesis via miR‐26a/HDAC6 axis after ischaemic stroke about?

Endogenous neurogenesis holds promise for brain repair and long-term functional recovery after ischaemic stroke. However, the effects of exosomes from human urine-derived stem cells (USC-Exos) in neurogenesis remain unclear. This study aimed to investigate whether USC-Exos enhanced neurogenesis and promoted functional recovery in brain ischaemia. By using an experimental stroke rat model, we found that intravenous injection of USC-Exos enhanced neurogenesis and alleviated neurological deficits in post-ischaemic stroke rats. We used neural stem cells (NSCs) subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) as an in vitro model of ischaemic stroke. The in vitro results suggested that USC-Exos promoted both proliferation and neuronal differentiation of NSCs after OGD/R. Notably, a further mechanism study revealed that the pro-neurogenesis effects of USC-Exos may be partially attributed to histone deacetylase 6 (HDAC6) inhibition via the transfer of exosomal microRNA-26a (miR-26a). Taken together, this study indicates that USC-Exos can be used as a novel promising strategy for brain ischaemia, which highlights the application of USC-Exos.

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Author

Xiaozheng Ling; Guowei Zhang; Yuguo Xia; Qingwei Zhu; Juntao Zhang; Qing Li; Xin Niu; Guowen Hu; Yunlong Yang; Yang Wang; Zhifeng Deng

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)