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Quantitation of Apoptotic Activity Following Castration in Human Prostatic Tissue in Vivo by Andrea Staack; Adrienne P. Kassis; Adam Olshen; Yuzhuo Wang; David Wu; Peter R. Carroll; Gary D. Grossfeld; Gerald R. Cunha; Simon W. Hayward is a Medicine article available to read on EtoBox.
What is Quantitation of Apoptotic Activity Following Castration in Human Prostatic Tissue in Vivo about?
## Abstract ## Background Androgen deprivation induces apoptosis in the prostate. Representative data, quantitating apoptotic activity in human prostatic epithelium following androgen ablation, are lacking. ## Methods Human prostatic tissue was grafted beneath the renal capsule of intact male athymic mice and allowed to become established. The mice were castrated and specimens were harvested on post‐castration day 0, 1, 2, 3, 4, 5, 7, 8, 9, 10, 14, 17, 18, and 21. Tissue was immediately fixed and apoptotic epithelial nuclei were identified. ## Results The percentage of terminal deoxynucleotidyl‐transferase‐mediated dUTP nick end‐labeling (TUNEL) positive epithelial cells increased from a baseline of 0.026%, peaked on post‐castration day 3 (1.54%), and returned to baseline by day 21. Mathematical analysis predicted that the observed apoptotic activity account for the loss of 87% of prostatic epithelial cells in 3 weeks. ## Conclusions Post‐castration apoptosis in human prostatic epithelium was low but was sufficient to account for the loss of nearly 90% of epithelial cells. Prostate 54: 212–219, 2003. © 2002 Wiley‐Liss, Inc.
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- Author
- Andrea Staack; Adrienne P. Kassis; Adam Olshen; Yuzhuo Wang; David Wu; Peter R. Carroll; Gary D. Grossfeld; Gerald R. Cunha; Simon W. Hayward
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)