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Indirect assessment of 4,4′-diphenylmethane diisocyanate (MDI) exposure by evaluation of specific humoral immune responses to MDI conjugated to human serum albumin by Boris D. Lushniak; Christopher M. Reh; David I. Bernstein; Joan S. Gallagher is a Medicine article available to read on EtoBox.

What is Indirect assessment of 4,4′-diphenylmethane diisocyanate (MDI) exposure by evaluation of specific humoral immune responses to MDI conjugated to human serum albumin about?

Background: A study of occupational asthma among workers exposed to 4,4Ј-Diphenylmethane Diisocyanate (MDI). Objective: To demonstrate if serum concentrations of MDI-specific IgG or IgE are sensitive biological markers of disease or of MDI exposure. Methods: The study group consisted of nine MDI-exposed workers and nine nonexposed workers. Air sampling for MDI and polymethylene polyphenyl isocyanate, occupational and medical histories, respiratory physical exams, pre-and postshift spirometry, and selfadministered peak expiratory flow rates were performed. Serum specific IgE and IgG antibodies to an MDI-human serum albumin (HSA) conjugate were assayed by the radioallergosorbent test and the enzyme-linked immunosorbent assay, respectively, and compared to nine nonexposed laboratory controls. Results: No definitive cases of occupational asthma were documented. The mean level of MDI-specific IgG was significantly greater among exposed workers compared to nonexposed workers and laboratory controls ( p ϭ 0.04). Mean levels of TDI and HDI-specific IgG were also increased. Conclusion: This study demonstrates that serum concentrations of MDI-specific IgG appear to be a moderately sensitive

Who reads Indirect assessment of 4,4′-diphenylmethane diisocyanate (MDI) exposure by evaluation of specific humoral immune responses to MDI conjugated to human serum albumin?

Author

Boris D. Lushniak; Christopher M. Reh; David I. Bernstein; Joan S. Gallagher

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0271-3586)

Published

1998

Language

EN

Field

Medicine (Health Sciences)