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Alanine Derivatives with Reactive Groups by B. Paul; W. Korytnyk is a Chemistry article available to read on EtoBox.
What is Alanine Derivatives with Reactive Groups about?
The synthesis of diazoketone analogs of amino acids and associated problems were investigated with N-phthaloyl-DL-alanine serving as a model. The carboxyl was activated by conversion to the acid chloride or, under mild conditions, to the mixed anhydride obtained with ethyl chloroformate or dicyclohexylcarbodiimide; the product was reacted with diazomethane. Deblocking the phthaloyl group with hydrazine gave 3-amino-1-diazo-2-butanone as a well-characterized solid salt and as a less stable oil. Further reactions of the blocked diazoketone of DL-alanine, such as conversion to alpha-haloketones, Wolff rearrangement, and deuterium exchange on C-1 were investigated. 3-A-mino-1-diazo-2-butanone had moderate inhibitory activity against mouse mammary adenocarcinoma in cell culture.
Who reads Alanine Derivatives with Reactive Groups?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- B. Paul; W. Korytnyk
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 1978
- Language
- EN
- Field
- Chemistry (Physical Sciences)