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Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers by T. Simon; L. Becquemont; B. Hamon; E. Nouyrigat; Y. Chodjania; J. M. Poirier; C. Funck-Brentano; P. Jaillon is a Medicine article available to read on EtoBox.
What is Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers about?
**Aims** To assess the age‐associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. **Methods** Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. **__Results__** PAX/CAF ratio variability was comparable regardless of age (intraindividual CV: 17.6 ± 6% and 16.2 ± 5.9%, interindividual CV: 48.1 ± 2.9% and 42.7 ± 3.6% in young and elderly, respectively). The PAX/CAF ratio was lower in elderly than in young subjects (95% CI for the difference: 0.004, 0.32) but the difference was not significant in nonsmokers compared separately. **Conclusions** The variability over time of the PAX/CAF ratio is not influenced by age.
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- Author
- T. Simon; L. Becquemont; B. Hamon; E. Nouyrigat; Y. Chodjania; J. M. Poirier; C. Funck-Brentano; P. Jaillon
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)