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Application of a Simultaneous Screening Method for the Detection of New Psychoactive Substances in Various Matrix Samples Using Liquid Chromatography/electrospray Ionization Tandem Mass Spectrometry and Liquid Chromatography/quadrupole Time‐of‐flight Mass Spectrometry by Nam Sook Kim; Na Young Lim; Hwan Seong Choi; Ji Hyun Lee; Hyungil Kim; Sun Young Baek is a Chemistry article available to read on EtoBox.

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## Rationale Recently, new psychoactive substances (NPS) have emerged as a public health risk. Particularly, their chemical structures are modified to avoid detection. Synthetic NPS with effects similar to those of illegal drugs have been recently detected and synthesized worldwide, including MDMB‐FUBINACA and APINAC, making it essential to rapidly and accurately detect NPS. ## Methods Fourteen NPS with similar structures were selected and their structures identified using ^1^H and ^13^C NMR spectroscopy. Additionally, we proposed the fragmentation pattern of each compound using liquid chromatography/quadrupole time‐of‐flight mass spectrometry (LC/QTOF‐MS). A simultaneous analytical method using liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS) was also developed and applied to real samples to detect the 14 NPS. The method was validated based on the specificity, linearity, limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, matrix effect, and stability according to international validation guidelines. ## Results The established method was used to screen 65 different matrix samples using LC/ESI‐MS/MS. By comparing the cal

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Author

Nam Sook Kim; Na Young Lim; Hwan Seong Choi; Ji Hyun Lee; Hyungil Kim; Sun Young Baek

Publisher

Wiley

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)