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Bioink Derived from Human Placenta Supporting Angiogenesis by Yongchao Duan; Wenhui Huang; Bo Zhan; Yuanyuan Li; Xue Xu; Kai Li; Xia Li; Xin Liu; Shenglong Ding; Shuo Wang; Jia Guo; Yukai Wang; Qi Gu is a Engineering article available to read on EtoBox.
What is Bioink Derived from Human Placenta Supporting Angiogenesis about?
Abstract Bioprinting is an emerging approach for constructing sophisticated tissue analogues with detailed architectures such as vascular networks, which requires bioink to fulfill the highly printable property and provide a cell-friendly microenvironment mimicking a native extracellular matrix (ECM). Here, we developed a human placental ECM-derived bioink (hp-bioink) meeting the requirements of 3D printing for printability and bioactivity. We first decellularized the human placenta, followed by enzymatic digestion, dialysis, lyophilization, and re-solubilization to convert the extracts into hp-bioink. Then, we demonstrated that 3%–5% of hp-bioink can be printed with self-standing and 1%–2% of hp-bioink can be embedded and printed within suspended hydrogels. Moreover, hp-bioink supports human umbilical vein endothelial cell assembly in vitro and angiogenesis in mice in vivo. Our research enriches the bank of human-derived bioinks, and provides a new opportunity to further accelerate bioprinting research and application.
Who reads Bioink Derived from Human Placenta Supporting Angiogenesis?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Yongchao Duan; Wenhui Huang; Bo Zhan; Yuanyuan Li; Xue Xu; Kai Li; Xia Li; Xin Liu; Shenglong Ding; Shuo Wang; Jia Guo; Yukai Wang; Qi Gu
- Publisher
- IOP Publishing
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)