Can I read Rapid and Precise Release from Nano‐Tracted Poly( N ‐isopropylacrylamide) Hydrogels Containing Linear Poly(acrylic acid) on EtoBox?

Rapid and Precise Release from Nano‐Tracted Poly( N ‐isopropylacrylamide) Hydrogels Containing Linear Poly(acrylic acid) by Taka‐aki Asoh; Tatsuo Kaneko; Michiya Matsusaki; Mitsuru Akashi is a Materials Science article available to read on EtoBox.

What is Rapid and Precise Release from Nano‐Tracted Poly( N ‐isopropylacrylamide) Hydrogels Containing Linear Poly(acrylic acid) about?

## Abstract **Summary:** We investigated the rapid and precise molecular release from hydrogels in response to dual stimuli. To achieve precise on/off drug release using thermoresponsive poly(__N__‐isopropylacrylamide) hydrogels, we prepared nano‐structured semi‐IPNs, which consisted of thermosensitive PNIPAAm networks penetrated by pH‐responsive poly(acrylic acid) (PAAc) linear chains and perforated to create nano‐tracts as a molecular pathway. The present nano‐tracted semi‐IPNs show a rapid deswelling response to both temperature and pH. Model drug releases were investigated when simultaneous changes in temperature and pH were applied. We observed that the cationic drug was rapidly released and then abruptly discontinued from the nano‐tracted semi‐IPNs in response to the dual stimuli, and clear release and stopping cycles were repeatedly observed on successive steps. Moreover, the release rates and amount of drug released were controllable by the deswelling speed of the gels and the PAAc content inside the gels. This novel release system using the nano‐tracted semi‐IPNs may be useful for the high performance, pulsed release of molecules. Release profiles of MB from semi‐IPNs at p

Who reads Rapid and Precise Release from Nano‐Tracted Poly( N ‐isopropylacrylamide) Hydrogels Containing Linear Poly(acrylic acid)?

Author

Taka‐aki Asoh; Tatsuo Kaneko; Michiya Matsusaki; Mitsuru Akashi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)

Published

2006

Language

EN

Field

Materials Science (Physical Sciences)