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CREM: a master-switch in the transcriptional response to cAMP by M Lamas; L Monaco; E Zazopoulos; E Lalli; K Tamai; L Penna; C Mazzucchelli; F Nantel; N S Foulkes; P Sassone-Corsi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is CREM: a master-switch in the transcriptional response to cAMP about?

The CREM gene encodes both repressors and activators of cAMP-dependent transcription in a tissue and developmentally regulated manner. In addition, multiple and cooperative phosphorylation events regulate the function of the CREM proteins. CREM plays a key physiological and developmental role within the hypothalamic-pituitary axis. There is a functional switch in CREM expression during the development of male germ cells which is directed by the pituitary hormone FSH . The CREM protein in germ cells is a powerful activator which appears to function as a master-switch in the regulation of postmeiotic genes. CREM is inducible by activation of the cAMP signalling pathway with the kinetics of an early response gene. The induction is transient, cell-specific, does not involve increased transcript stability and does not require protein synthesis. The subsequent decline in CREM expression requires __de novo__ protein synthesis. The induced transcript encodes ICER and is generated from an alternative, intronic promoter. ICER functions as a powerful repressor of cAMP-induced transcription, and represses the activity of its own promoter, thus constituting a negative autoregulatory loop.

Who reads CREM: a master-switch in the transcriptional response to cAMP?

Author

M Lamas; L Monaco; E Zazopoulos; E Lalli; K Tamai; L Penna; C Mazzucchelli; F Nantel; N S Foulkes; P Sassone-Corsi

Publisher

The Royal Society

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)