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Can I read Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression on EtoBox?
Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression by Barbara L. Wehde; Patrick D. Rädler; Hridaya Shrestha; Stevi J. Johnson; Aleata A. Triplett; Kay-Uwe Wagner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression about?
Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential for IL-6-class inflammatory cytokine signaling and plays a critical role in metastatic cancer progression. JAK1 is indispensable for the oncogenic activation of STAT1, STAT3, and STAT6 in ERBB2-expressing cancer cells, suggesting that ERBB2 receptor tyrosine kinase complexes do not directly activate these STAT proteins in vivo. A genome-wide gene expression analysis revealed that JAK1 signaling has pleiotropic effects on several pathways associated with cancer progression. We established that FOS and MAP3K8 are targets of JAK1/STAT3 signaling, which promotes tumorsphere formation and cell migration. The results highlight the significance of JAK1 as a rational therapeutic target to block IL-6-class cytokines, which are master regulators of cancer-associated inflammation.
Who reads Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Barbara L. Wehde; Patrick D. Rädler; Hridaya Shrestha; Stevi J. Johnson; Aleata A. Triplett; Kay-Uwe Wagner
- Publisher
- Elsevier ; Cell Press; Amsterdam: Elsevier; Research Square; Elsevier BV (ISSN 2211-1247)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)