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Twenty-year Effects of Antipsychotics in Schizophrenia and Affective Psychotic Disorders by Martin Harrow; Thomas H Jobe; Liping Tong is a Medicine article available to read on EtoBox.

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## Abstract ## Background Studies that examine course and outcome in psychosis have reported considerable heterogeneity in terms of recovery, remission, employment, symptom presentation, social outcomes, and antipsychotic medication effects. Even with demonstrated heterogeneity in course and outcome, prophylactic antipsychotic maintenance therapy remains the prominent practice, particularly in participants with schizophrenia. Lack of efficacy in maintenance antipsychotic treatment and concerns over health detriments gives cause to re-examine guidelines. ## Methods This study was conducted as part of the Chicago follow-up study designed as a naturalistic prospective longitudinal research study to investigate the course, outcome, symptomatology, and effects of antipsychotic medication on recovery and rehospitalization in participants with serious mental illness disorders. A total of 139 participants with 734 observations were included in the analysis. GEE logistic models were applied to adjust for confounding factors measured at index hospitalization and follow-ups. ## Results Our data show that the majority of participants with schizophrenia or affective psychosis experience future

Who reads Twenty-year Effects of Antipsychotics in Schizophrenia and Affective Psychotic Disorders?

Author

Martin Harrow; Thomas H Jobe; Liping Tong

Publisher

Cambridge University Press (CUP)

Published

2021

Language

EN

Field

Medicine (Social Sciences)