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Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide by Kenneth Maiese is a book available to read on EtoBox.

What is Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide about?

Metabolic disorders including diabetes mellitus (DM) are considered a significant component of the increasing prevalence of noncommunicable diseases (NCDs) occurring throughout the world. It is predicted that the number of individuals with DM is expected to rise to 700 million individuals by the year 2045. Furthermore, the care for disorders such as DM can consume more than 17% of the Gross Domestic Product in nations such as the United States. Given that present therapies for metabolic disorders may offer some clinical benefit and gradually slow disease progression, metabolic diseases can affect multiple organs of the body and ultimately lead to disability and death. Given these challenges, the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and its associated pathways with AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the vitamin nicotinamide offer exciting prospects for the development of innovative therapeutic strategies that are highly warranted. SIRT1 is intimately tied to AMPK, mTOR, and nicotinamide during metabolic disease to limit oxidative stress, increase life span, improve insulin sensitivi

Author

Kenneth Maiese

Published

2021

Language

EN