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Effects of Surfaces and Macromolecular Crowding on Bimolecular Reaction Rates by Andrews, Steven S is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Effects of Surfaces and Macromolecular Crowding on Bimolecular Reaction Rates about?

Biological cells are complex environments that are densely packed with macromolecules and subdivided by membranes, both of which affect the rates of chemical reactions. It is well known that crowding reduces the volume available to reactants, which increases reaction rates, and also inhibits reactant diffusion, which decreases reaction rates. This work investigates these effects quantitatively using analytical theory and particle-based simulations. A reaction rate equation based on only these two processes turned out to be inconsistent with simulation results. However, accounting for diffusion inhibition by the surfaces of nearby obstacles, which affects access to reactants, it led to perfect agreement for reactions near impermeable planar membranes and improved agreement for reactions in crowded spaces. A separate model that quantified reactant occlusion by crowders, and extensions to a thermodynamic 'cavity' model proposed by Berezhkovskii and Szabo [25], were comparably successful. These results help elucidate reaction dynamics in confined spaces and improve prediction of in vivo reaction rates from in vitro ones.

Who reads Effects of Surfaces and Macromolecular Crowding on Bimolecular Reaction Rates?

Author

Andrews, Steven S

Publisher

Institute of Physics; IOP Publishing; Institute of Physics Publishing (ISSN 1478-3967)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)