Can I read Catalytic Reductive Recyclization of Functionalized Isoxazoline N -Oxides to Pyrrolizidine-3-ones on EtoBox?

Catalytic Reductive Recyclization of Functionalized Isoxazoline N -Oxides to Pyrrolizidine-3-ones by Ilya V. Okladnikov; Svetlana A. Aksenova; Sema L. Ioffe; Alexey Yu. Sukhorukov is a Chemistry article available to read on EtoBox.

What is Catalytic Reductive Recyclization of Functionalized Isoxazoline N -Oxides to Pyrrolizidine-3-ones about?

Pyrrolizidine is among the saturated N-heterocyclic scaffolds most frequently found in natural products and pharmaceutically relevant substances. Herein, a strategy for the synthesis of polysubstituted pyrrolizidine-3-ones by catalytic reductive domino-type recyclization of properly functionalized isoxazoline N-oxides was developed. The process is diastereoselective, and one diastereomer (out of four possible ones) is predominant in many of the studied cases. Using the developed method, modifications of potent GSK's PDE4 inhibitor and MSD's potent hNK 1 antagonist were prepared.

Who reads Catalytic Reductive Recyclization of Functionalized Isoxazoline N -Oxides to Pyrrolizidine-3-ones?

Author

Ilya V. Okladnikov; Svetlana A. Aksenova; Sema L. Ioffe; Alexey Yu. Sukhorukov

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)