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Angiocentric lymphoma with granulomatous panniculitis in the skin expressing natural killer cell and large granular T-cell phenotypes by M. Takeshita; K. Ohshima; K. Kikuchi; R. Watanabe; T. Okamura; H. Goto is a Medicine article available to read on EtoBox.

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We investigated three patients suffering from angiocentric lymphoma with granulomatous panniculitis in the skin. All three patients presented with multiple purple subcutaneous nodules. Immunohistologically, the lymphoma cells in all three patients expressed CD2 (T-11), CD56 (neural cell adhesion molecule), and Mik-fll (interleukin-2fl receptor). CD3s (CD3, Leu-4)-positive lymphoma cells were found in two patients. A poreforming protein (perforin) was detected in the lymphoma cells of all three patients. Perforin-possessing lymphoid cells were focally scattered in 2 of 15 patients with CD56-negative cutaneous lymphomas who served as controls. By the Southern blot method, one patient showed a rearranged T-cell receptor (TcR)fl gene in the biopsied specimen, and the other two patients had germline configurations of TcRs and immunoglobulin heavy chain genes. One patient had serum anti-human T-cell lymphotropic virus (HTLV)-I antibody, but showed no integration of its proviral DNA. Ultrastructurally, membrane-bound azurophilic granules were detected in the atypical lymphoid cells of all three patients. Angiocentric lymphoma with panniculitis in three patients showed the characteristics

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Author

M. Takeshita; K. Ohshima; K. Kikuchi; R. Watanabe; T. Okamura; H. Goto

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1432-2307)

Published

1994

Language

EN

Field

Medicine (Health Sciences)