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Identification of Levothyroxine Antichagasic Activity Through Computer-Aided Drug Repurposing by Roger Rodriguez is a document available to read on EtoBox.
What is Identification of Levothyroxine Antichagasic Activity Through Computer-Aided Drug Repurposing about?
The research article identifies the antichagasic activity of levothyroxine through computer-aided drug repurposing, focusing on its inhibition of cruzipain, a key enzyme in Trypanosoma cruzi, the causative agent of Chagas disease. A virtual screening campaign was conducted using a dataset of known cruzipain inhibitors, leading to the selection of 54 FDA-approved drugs, among which levothyroxine demonstrated significant antiproliferative effects on the parasite. This study highlights the potential of repurpo
- Author
- Roger Rodriguez
- Language
- EN