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Synthesis and cell attachment activity of bioactive oligopeptides: RGD, RGDS, RGDV, and RGDT by Yoshiaki Hirano; Yoshihiro Kando; Toshio Hayashi; Kunio Goto; Akio Nakajima is a Medicine article available to read on EtoBox.

What is Synthesis and cell attachment activity of bioactive oligopeptides: RGD, RGDS, RGDV, and RGDT about?

Tetrapeptides, Arg-Gly-Asp-Ser (RGDS), Arg-Gly-Asp-Val (RGDV), a n d A r g -Gly-Asp-Thr (RGDT), p r e s e n t i n t h e cell-attachment domain of fibronectin, vitronectin, and collagen, respectively, were synthesized by using an improved liquid-phase procedure. Bioactivities of RGD and RGDX (X = S, V, and T) as cell recognition determinants were investigated by two methods to evaluate interactions of these oligopeptides with L-929 fibroblast cells originating i n mouse epithelia. In t h e first method, these o l i g o p e p t i d e s w e r e i m m o b i l i z e d t o ethylene-acrylic acid copolymer (EAA) film, and the cell-attachment activity of the immobilized film was measured. In t h e s e c o n d m e t h o d , i n t e r a c t i o n of oligopeptides with the cells was evaluated by measuring the cell inhibition caused by oligopeptides. It was found that RGD and RGDX exhibit remarkable cellattachment activity, and the activity of oligopeptides depends on X.

Who reads Synthesis and cell attachment activity of bioactive oligopeptides: RGD, RGDS, RGDV, and RGDT?

Author

Yoshiaki Hirano; Yoshihiro Kando; Toshio Hayashi; Kunio Goto; Akio Nakajima

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1991

Language

EN

Field

Medicine (Health Sciences)