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Can I read Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers on EtoBox?
Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers by Benedikt Cramer; Henning Harrer; Kazuhiko Nakamura; Daisuke Uemura; Hans-Ulrich Humpf is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers about?
The mycotoxin ochratoxin A is a potent inhibitor of the protein biosynthesis and known to be cytotoxic in nanomolar concentrations. In order to investigate the relationship between stereochemistry and cytotoxicity of this compound, all four ochratoxin A stereoisomers have been synthesized. Using the liver cell line Hep G2, the compounds were tested for cytotoxic and apoptotic potential. It could be shown, that the l-configuration of the phenylalanine moiety of the molecule is mostly responsible for the high cytotoxicity of ochratoxin A while the stereocenter at the dihydroisocoumarine structure is of less importance.
Who reads Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Benedikt Cramer; Henning Harrer; Kazuhiko Nakamura; Daisuke Uemura; Hans-Ulrich Humpf
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)