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NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation by Nagalakshmi Nadiminty; Jae Yeon Chun; Wei Lou; Xin Lin; Allen C. Gao is a Medicine article available to read on EtoBox.

What is NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation about?

## Abstract ## PURPOSE Androgen‐deprivation therapy only causes a temporary regression of prostate cancer, as all tumors will eventually progress to refractory to hormonal therapy after 1–3 years of treatment. The underlying mechanisms of prostate cancer androgen refractory progression are incompletely understood. In this study, we employed in vitro as well as in vivo models to examine the role of NF‐κB2/p52 in prostate cancer growth and androgen independent progression. ## EXPERIMENTAL DESIGN The effects of NF‐κB2/p52 on cell growth, androgen responsiveness, cell cycle and apoptosis were examined in androgen sensitive LNCaP cells. The effect of NF‐κB2/p52 on tumor growth was examined in intact and castrated male mice. ## RESULTS Overexpression of NF‐κB2/p52 enhances androgen‐sensitive LNCaP human prostate cancer cell growth and clonogenic ability in androgen‐deprived condition in vitro. NF‐κB2/p52 induced androgen‐independent growth is through protecting LNCaP cells from apoptotic cell death and cell cycle arrest induced by androgen‐deprivation. In addition, NF‐κB2/p52 stimulates Cyclin D1 expression and knock down of Cyclin D1 expression by siRNA abolished NF‐κB2/p52‐induced cell

Who reads NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation?

Author

Nagalakshmi Nadiminty; Jae Yeon Chun; Wei Lou; Xin Lin; Allen C. Gao

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2008

Language

EN

Field

Medicine (Health Sciences)