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Can I read Chromosome Balance and the Control of Malignancy on EtoBox?
Chromosome Balance and the Control of Malignancy by Navah Bloch‐Shtacher; Leo Sachs is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Chromosome Balance and the Control of Malignancy about?
The Giemsa banding pattern of the chromosomes has been analyzed in a line of transformed golden hamster cells, revertant and re-revertant cells and their tumors. The transformed and re-revertant cells were malignant in vivo and had gained an additional chromosome 5(7). Revertants with a suppression of malignancy lost this additional chromosome 5(7) and gained an additional chromosome 7(2). The tumors produced by segregants from the revertant cells were malignant, although to a lower degree than transformed and re-revertant cells. These tumors had lost the additional chromosome 7(2) found in revertants and gained one or two 5(12) chromosomes. The results support the hypothesis that the balance between genes for expression and suppression controls malignancy. The data indicate that chromosome 7(2) carries genes for suppression and that chromosomes 5(7) and 5(12) carry genes for expression of malignancy. The genes on chromosome 5(7) seem to result in a greater degree of expression than the genes on chromosome 5(12). The chromosome balance that controlled malignancy in these cells, also controlled the expression and suppression of transformed properties in vitro.
Who reads Chromosome Balance and the Control of Malignancy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Navah Bloch‐Shtacher; Leo Sachs
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1976
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)