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The Role of Neutrophils in Corneal Nerve Regeneration by Xiaowen Zhao; Minghong Zhang; Fengjiao Li; Cuiping Ma; Dianqiang Wang; Ye Wang is a Medicine article available to read on EtoBox.

What is The Role of Neutrophils in Corneal Nerve Regeneration about?

## Background To investigate the role of neutrophils in corneal nerve regeneration. ## Methods A mouse model simulating corneal nerve injury was established and samples from corneal scraping with and without neutrophil closure were collected. These samples were used for corneal nerve staining, ribonucleic acid sequencing, and bioinformatics. Differential expression analysis was used to perform enrichment analysis to identify any significant differences between these two groups. The differential genes were then intersected with neutrophil-associated genes and a protein-protein interaction network was constructed using the intersected genes. The immune infiltration between the two groups was examined along with the immune cell variation between the high and low gene expression groups. ## Results Neutrophil removal delays corneal epithelial and nerve regeneration. A total of 546 differential genes and 980 neutrophil-associated genes, with 27 genes common to both sets were obtained. Molecular Complex Detection analysis yielded five key genes, namely integrin subunit beta 2 (__ITGB2__), matrix metallopeptidase 9 (__MMP9__), epidermal growth factor (__EGF__), serpin family E member 1 (__

Who reads The Role of Neutrophils in Corneal Nerve Regeneration?

Author

Xiaowen Zhao; Minghong Zhang; Fengjiao Li; Cuiping Ma; Dianqiang Wang; Ye Wang

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)