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Effects of Aging on Hydrocephalus After Intraventricular Hemorrhage by Wan, Yingfeng; Gao, Feng; Ye, Fenghui; Yang, Weiming; Hua, Ya; Keep, Richard F.; Xi, Guohua is a Neuroscience article available to read on EtoBox.

What is Effects of Aging on Hydrocephalus After Intraventricular Hemorrhage about?

## Background Hydrocephalus is a common and major complication that affects outcome after intraventricular hemorrhage (IVH). While aging impacts the occurrence of hydrocephalus in patients with IVH this and the underlying mechanisms have received little attention. The present investigation, therefore, studied the impact of aging on hydrocephalus after IVH in a rat model. ## Methods Young and aged (3 and 18 months old, respectively) male Fischer 344 rats had an intraventricular injection of 200 μl autologous blood or saline. Ventricular volume was estimated using magnetic resonance imaging (MRI), while ventricular wall damage, heme oxygenase-1 (HO-1) and epiplexus cell activation were quantified by histological staining and Western blot. Additionally, the impact of intraventricular iron injection was examined in young and aged rats. ## Results Intraventricular injection of autologous blood induced hydrocephalus in both young and aged rats but ventricular volumes were larger in aged rats compared to young rats from day 3 to day 14 followed IVH. In addition, ventricular wall damage and periventricular HO-1 upregulation were greater in aged versus young rats on day 1 after IVH. Aged ra

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Author

Wan, Yingfeng; Gao, Feng; Ye, Fenghui; Yang, Weiming; Hua, Ya; Keep, Richard F.; Xi, Guohua

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central; Springer Science and Business Media LLC; Springer Nature (ISSN 2045-8118)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)