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An LC method for the simultaneous screening of some common counterfeit and sub-standard antibiotics: Validation and uncertainty estimation by M.C. Gaudiano; A. Di Maggio; E. Antoniella; L. Valvo; P. Bertocchi; L. Manna; M. Bartolomei; S. Alimonti; A.L. Rodomonte is a Chemistry article available to read on EtoBox.
What is An LC method for the simultaneous screening of some common counterfeit and sub-standard antibiotics: Validation and uncertainty estimation about?
Pharmaceutical counterfeiting is a worldwide public health problem, often under-recognised, especially in developing countries where the percentage of counterfeit and sub-standard medicines is dramatically high. Antibiotics, among the most widespread drugs, have been particularly targeted by counterfeiters. World Health Organization emphasizes the need for development and distribution of screening methods explicitly targeted to counterfeit drugs. In this paper is presented a single method for the simultaneous analysis of some of the most common and counterfeited essential antibiotics: ampicillin, amoxicillin + clavulanic acid, doxycycline, cloxacillin, chloramphenicol. A full validation was performed in terms of linearity, precision, robustness and trueness; an assessment of uncertainty was carried out exploiting these data. A wide linearity range was investigated considering the specific nature of counterfeit and sub-standard drugs, whose content in active substance may be rather far from the declared amount. A large span in robustness parameters was considered and a complete intermediate precision assessment was conducted, envisaging the possibility of transferring the method to
Who reads An LC method for the simultaneous screening of some common counterfeit and sub-standard antibiotics: Validation and uncertainty estimation?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- M.C. Gaudiano; A. Di Maggio; E. Antoniella; L. Valvo; P. Bertocchi; L. Manna; M. Bartolomei; S. Alimonti; A.L. Rodomonte
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)