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Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways by Mei Meng; Yan Guo; Yu Chen; Xu Li; Bin Zhang; Zhijia Xie; Juntao Liu; Zhe Zhao; Yuxi Liu; Tong Zhang; Yingnan Qiao; Bingxue Shang; Quansheng Zhou is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways about?

## Abstract ## Background Cancer/testis antigen-45A1 (CT45A1) is overexpressed in various types of cancer but is not expressed in healthy women. The role of CT45A1 in cervical cancer has not yet been described in the literature. ## Purpose The aim of this research was to study the role of CT45A1 in cervical cancer progression and drug resistance, elucidate the mechanisms underlying CT45A1-mediated tumorigenesis and investigate CT45A1 as a biomarker for cervical cancer diagnosis, prognostic prediction, and targeted therapy. ## Methods The CT45A1 levels in the tumors from cervical cancer patients were measured using immunohistochemical staining. The role and mechanisms underlying CT45A1-mediated cervical cancer cell tumor growth, invasion, and drug resistance were studied using xenograft mice, cervical cancer cells, immunohistochemistry, RNA-seq, real-time qPCR, Chromatin immunoprecipitation and Western blotting. ## Results CT45A1 levels were notably high in the tumor tissues of human cervical cancer patients compared to the paracancerous tissues (__p__ < 0.001). Overexpression of CT45A1 was closely associated with poor prognosis in cervical cancer patients. CT45A1 promoted cervical

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Author

Mei Meng; Yan Guo; Yu Chen; Xu Li; Bin Zhang; Zhijia Xie; Juntao Liu; Zhe Zhao; Yuxi Liu; Tong Zhang; Yingnan Qiao; Bingxue Shang; Quansheng Zhou

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)