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Can I read CD163‐positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation on EtoBox?
CD163‐positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation by Babs O. Fabriek; Elise S. Van Haastert; Ian Galea; Machteld M.J. Polfliet; Ed D. Döpp; Michel M. Van Den Heuvel; Timo K. Van Den Berg; Corline J.A. De Groot; Paul Van Der Valk; Christine D. Dijkstra is a Neuroscience article available to read on EtoBox.
What is CD163‐positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation about?
## Abstract Perivascular macrophages (PVM) constitute a subpopulation of resident macrophages in the central nervous system (CNS) that by virtue of their strategic location at the blood‐brain barrier potentially lend themselves to a variety of important functions in both health and disease. Functional evidence suggests that PVM play a supportive role during experimental autoimmune encephalomyelitis in rodents. However, the function of PVM in the human CNS remains poorly characterized. We first set out to investigate the validity of the antibody EDhu1, which recognizes human CD163, to specifically identify human PVM. Second, we wanted to gain insight into the function of PVM in antigen recognition and presentation and therefore we studied the expression of DC‐SIGN, mannose receptor, MHC class II, and several costimulatory molecules by PVM in the normal and inflamed human CNS (multiple sclerosis (MS) brain lesions). Conventional immunohistochemistry and double‐labeled immunofluorescence techniques were used. We show that CD163 specifically reveals PVM in the normal human CNS. In MS lesions, CD163 staining reveals expression on foamy macrophages and microglia, besides an upregulation
Who reads CD163‐positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Babs O. Fabriek; Elise S. Van Haastert; Ian Galea; Machteld M.J. Polfliet; Ed D. Döpp; Michel M. Van Den Heuvel; Timo K. Van Den Berg; Corline J.A. De Groot; Paul Van Der Valk; Christine D. Dijkstra
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2005
- Language
- EN
- Field
- Neuroscience (Life Sciences)