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Adult Weight Change and Incidence of Premenopausal Breast Cancer by Karin B. Michels; Kathryn L. Terry; A. Heather Eliassen; Susan E. Hankinson; Walter C. Willett is a Medicine article available to read on EtoBox.

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## Abstract Overweight and obesity are inversely related to the risk of breast cancer among premenopausal women. We assessed the association between adult weight change since age 18 years with the risk of breast cancer among premenopausal women to explore whether weight gain was associated with a decrease in risk and weight loss was associated with an increase in risk. A total of 56,223 premenopausal participants in the Nurses' Health Study and 109,385 premenopausal participants in the Nurses' Health Study II were prospectively followed for up to 32 years and 18 years, respectively, and weight change since age 18 years was assessed biennially. The incidence of invasive breast cancer was assessed throughout follow‐up. Weight loss of 5 kg or more since age 18, maintained for at least 4 years, was related to lower incidence of premenopausal breast cancer, compared to maintaining a stable weight, but this relation was of borderline statistical significance (covariate‐adjusted HR = 0.75; 95% CI 0.52–1.09). Weight gain since age 18 years was also inversely related to breast cancer incidence among premenopausal women (covariate‐adjusted __p__ for trend = 0.01), but the association weakene

Who reads Adult Weight Change and Incidence of Premenopausal Breast Cancer?

Author

Karin B. Michels; Kathryn L. Terry; A. Heather Eliassen; Susan E. Hankinson; Walter C. Willett

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2011

Language

EN

Field

Medicine (Health Sciences)